Professor Colin Kleanthous

In my laboratory we aim to understand how protein-protein interactions (PPIs) in bacteria underpin signalling within the cell envelope and cytoplasm, how changes in the environment modify these interactions to elicit different cellular responses and how such interactions are subverted by antibacterial proteins to catalyse their import into the cell. We study PPIs from a number of bacteria but predominantly from the model Gram-negative organism Escherichia coli. 

The Maiden Lab currently holds a collaborative research grant with Colin, funded by the Wellcome Trust, titled: 'Protein Antibiotics: Discovery, mode of action and development'.